Articles >Why Series > Why Fixderma Epifager Regale Works?
Why Fixderma Epifager Regale Works?
 
 
Manufactured by: Fixderma India Pvt. Ltd.
Under Technical Guidance of Fixderma LLC., USA
Imported & Distributed by: EON Pharmatek, Inc. Philippines

 
This intensive, corrective cream reduces skin discoloration by shedding dark skin cells & inhibits excess melanin production within the cell, increasing the skin’s radiance and lightening dark pigmentation.
 
Skin lightening proven ingredients
Daisy flower (Bellis perennis) extract,
Emblica fruit extract,
Gatulina Whitening,
Sulfora White, and
Nanowhite
Makes Fixderma Epifager Regale a highly efficient product to deliver a natural skin whitening and brightening effect.
 
Likewise, 1% Emblica fruit extract provides a triple activity for brightening the skin. This helps in reducing acne and freckle spots. The age defying property is due to its antioxidant character. [1]
 
Further brightening and lightening effect is attributed to the 1.5% Gatulina Whitening. This is a mixture of Kojic acid [3], Lactic acid, and a Liquorice extract [2] combined with a penetration enhancer, Ethoxydiglycol.
 
Highly effective combination of ingredients for treating hyper-pigmentation, lesions, melasma & solar lentigine.
 
Supplemental benefit from 1% Pentavitin makes Fixderma Epifager Regale a highly effective moisturizer. Its composition is similar to natural carbohydrate fraction found in stratum corneum of human skin. [8]

Whitening property of 0.5% Sulfora White also effectively inhibits pigmentation by targeting two key upstream reaction steps in the melanin cascade. [9]

Lastly, the unique 0.5% Nanowhite
Triple activity of the natural Arbutin, Lecithin [6], Linolenic acid, Vitamin E, Glutathione [10] and Vitamin C [5] enhance the skin brightening property of the cream.

Fixderma Epifager Regale has a combination of
powerful whitening and brightening agents with potent anti-oxidants.

This can prevent melanin synthesis, help reduce the appearance of spots ,brighten & even skin tone while leaving your skin feel soft , supple and youthful.

 
References

•Babitha, S., Shin, J. H., & Kim, E. K. (2009). Potential Skin Whitening Agents of Natural Origin from South Asian Region. Journal of the Society of Cosmetic Scientists of Korea, 35(1), 1-9.
•Briganti, S., Camera, E., & Picardo, M. (2003). Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Research, 16(2), 101-110.
•Cabanes, J., Chazarra, S., & Garcia- Carmona, F. (1994). Kojic Acid, a Cosmetic Skin Whitening Agent, is a Slow‐binding Inhibitor of Catecholase Activity of Tyrosinase. Journal of Pharmacy and Pharmacology, 46(12), 982-985.
•John, S., Lorenz, P., Petersen, R. D., Heldermann, M., & Borchert, S. (2005). Skin-lightening agent with different pathways of action on melanogenesis. SOFW JOURNAL, 131(7), 40.
•Lin, H. T., Chen, G. S., Yen, F. L., & Chen, K. N. (2016). Objective and Self-Perceived Facial Skin Status Using Whitening Efficacy of Cosmetic Products on Taiwanese Women. Journal of Cosmetics, Dermatological Sciences and Applications, 6(04), 117.
•Maeda, K., & Fukuda, M. (1991). In vitro effectiveness of several whitening cosmetic components in human melanocytes. J Soc Cosmet Chem, 42(42), 361-8.
•Pfaff, G., & Becker, M. (2012). Special effect pigments in cosmetics applications. Household Personal Hold, 7(1), 12-15.
•Pentapharm (2009). Pentavitin®: Binds to Keratin in Skin to Keep the Moisture Balance. Retrieved from http://www.cosmeticsonline.com.br/subcategorias/SUB19_DSM%20PENTAVITIN.pdf
•Schmid, D. (2008). SulforaWhite: Garden Cress Sprout Fraction with Strong Whitening Activity. Cosmetic Science Technology. 1-4.
•Sonthalia, S., Daulatabad, D., Sarkar, R. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol , 82, 262-72.
•Usuki, A., Ohashi, A., Sato, H., Ochiai, Y., Ichihashi, M., & Funasaka, Y. (2003). The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Experimental dermatology, 12(s2), 43-50.
 
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